ANALYSIS OF ADVERSE PROGNOSTIC FACTORS IN ENDOMETRIAL CANCER
Keywords:
morphology, endometrioid adenocarcinoma.Abstract
Endometrial cancer in patients over 50 years old, compared with the group of 60-75 years old, is characterized by a predominance of high-grade carcinomas (27.2% versus 12%, p < 0.001) due to the prevalence of non-endometrioid tumor histotype (16.98% versus 4.7%, p = 0.005). Extensive forms of the disease (FIGO stages III-IV) among women aged ≥ 70 years were observed in 17.6% of cases versus 6.7% in the comparison group (p = 0.003). The studied age groups were comparable in the extent of surgical treatment (p = 0.637) and adjuvant therapy performed in the postoperative period (p = 0.749).
References
1.Endometrial cancer of the very elderly: management and survival in the Francogyn population / F.A. Martin, L. Dion , K. N. Timoh [et al.] // Eur J Surg Oncol. – 2023. – Vol. 49 (5). – P. 1023-1030.
2. Endometrial cancer: ESMO clinical practice guideline for diagnosis, treatment and follow-up / A. Oaknin, T.J. Bosse, C.L. Creutzberg [et al.] // Ann Oncol. – 2022. – Vol. 33 (9). – P. 860-877.
3. Endometrial carcinoma molecular subtype correlates with the presence of lymph node metastases / A. Jamieson, E.F. Thompson, J. Huvila [et al.] // Gynecol Oncol. – 2022. – Vol. 165 (2). P. 376-384.
4. Khamdamova M.T., Zhaloldinova M.M., Khamdamov I.B. The state of nitric oxide in the blood serum of patients with cutaneous leishmaniasis // New Den Medicine. - Bukhara, 2023. - № 5 (55). - Р. 638-643.
5. Khamdamova M.T., Zhaloldinova M.M., Khamdamov I.B. The value of ceruloplasmin and copper in the blood serum of women wearing copper-containing intrauterine devices // New Den Medicine. - Bukhara,2023. - № 6 (56). - Р. 2-7.
6. Khamdamova M.T., Khasanova M.T. Various mechanisms of pathogenesis of endometrial hyperplasia in postmenopausal women (literature review)// New Den Medicine. - Bukhara, 2023. - № 8 (58). - Р. 103-107.
7. Khamdamova M.T., Akramova D.E. Genetic aspects of genital prolapse in women of reproductive age // New Den Medicine. - Bukhara, 2024. - № 2 (64). - Р.420-426.
8. Khamdamova M.T., Akramova D.E. Immediate and long-term results of surgical treatment of genital prolapse in elderly women // New Den Medicine. - Bukhara, 2025. - № 3 (77). - Р. 201-207.
9.Khamdamova M.T., Akramova D.E. Efficiency of various methods of treatment of women with genital prolapse // News of dermatovenerology and reproductive health. - Tashkent, 2025. - № 2 (109). - Р.30-33.
10. Khamdamova M.T., Khasanova M.T. genetic mechanisms of development of endometrial hyperplastic processes in women in menopacteric age)// New Den Medicine. - Bukhara, 2025. - № 3 (77). - Р. 207-211.
11.Khamdamova M.T., Khasanova M.T. Морфологические изменения эндометрия при гиперплазии // Новости дерматовенерологии и репродуктивного здоровья.-Ташкент.-2025.- № 2 (109). - Р. 12-14.
12. Khamdamova M.T., Umidova N.N. Генитальный эндометриоз – болезнь активных и деловых женщин // Новости дерматовенерологии и репродуктивного здоровья.-Ташкент.-2025.- № 2 (109). - Р. 33-14.
13. Khamdamova M.T., Akramova D.E. Генетические аспекты генитального пролапса у женщин репродуктивного возраста) // New Den Medicine. - Bukhara, 2024. - № 2 (64). - Р. 420-426.
14. Evaluation of treatment effects in patients with endometrial cancer and POLE mutations: An individual patient data meta-analysis / J.N. McAlpine, D.S. Chiu, R.A. Nout [et al.] // Cancer. – 2021. - Vol. 127 (14). – P. 2409-2422.
15. Exclusion of older adults from cancer clinical trials: review of the literature and future recommendations / I.M. Bumanlag, J.A. Jaoude, M.K. Rooney [et al.] // Semin Radiat Oncol. – 2022. – Vol. 32 (2). – P. 125-134.



