PERSONALIZATION OF TREATMENT AND PREVENTION TACTICS IN THE EARLY STAGES OF AVASCULAR NECROSIS OF THE HIP BONE BASED ON CLINICAL AND GENETIC PROFILING
Keywords:
To evaluate the effectiveness of a personalized approach to the treatment and prevention of the progression of early stages of ANFH, taking into account the polymorphism of the PPARγ gene (Pro12Ala), compared to standard treatment tactics.Abstract
Avascular necrosis of the femoral head (ANFH) is a progressive degenerative-dystrophic disease that leads to persistent pain, limited mobility, and a significant decrease in the quality of life in patients of working age. The traditional assessment of patients' condition, which is based primarily on the radiological characteristics of the disease stage, does not always allow for predicting the rate of progression and the individual response to conservative therapy. Therefore, the integration of molecular genetic parameters into the algorithms for selecting treatment and rehabilitation strategies is of particular interest. One of the promising areas is the study of PPARγ gene polymorphism, which is associated with lipid metabolism, osteogenesis, and bone remodeling, and may have a direct impact on the course of ANFH and the effectiveness of early pathogenetic intervention.
