EPIDEMIOLOGICAL CHARACTERISTICS OF CERVICAL INTRAEPITHELIAL NEOPLASIA ASSOCIATED WITH HUMAN PAPILLOMAVIRUS
Abstract
Cervical intraepithelial neoplasia (CIN) is a common precancerous condition among women and represents a key precursor stage of cervical cancer. Modern epidemiological studies demonstrate that human papillomavirus (HPV), particularly high-risk types 16 and 18, plays a leading role in the development of CIN. According to available data, HPV is detected in 90–99% of CIN II–III cases (Schiffman et al., 1993). The widespread prevalence of HPV infection and its significant socio-economic burden determine the high relevance of this problem.
References
1. Schiffman, M.H., Bauer, H.M., Hoover, R.N. et al. (1993). Epidemiologic evidence showing that human papillomavirus infection causes most cervical intraepithelial neoplasia. Journal of the National Cancer Institute, 85(12), 958–964.
https://academic.oup.com/jnci/article-abstract/85/12/958/1085600
2. Stanley, M. (2010). Pathology and epidemiology of human papillomavirus infection in females. Gynecologic Oncology, 117(2 Suppl), S5–S10.
https://www.sciencedirect.com/science/article/pii/S0090825810000879
3. Franco, E.L., Schlecht, N.F., Saslow, D. (2003). The epidemiology of cervical cancer. The Cancer Journal, 9(5), 348–359.
https://journals.lww.com/journalppo/abstract/2003/09000/the_epidemiology_of_cervical_cancer.4.aspx
4. Zhao, F.H., Lewkowitz, A.K., Hu, S.Y. et al. (2012). Prevalence of human papillomavirus and cervical intraepithelial neoplasia in China: a pooled analysis. International Journal of Cancer.
https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.27571
5. Kalliala, I., Athanasiou, A., Veroniki, A.A. et al. (2020). Incidence and mortality from cervical cancer after treatment of CIN: a systematic review. Annals of Oncology.
https://www.sciencedirect.com/science/article/pii/S0923753419390854
6. Holly, E.A. (1996). Cervical intraepithelial neoplasia, cervical cancer, and HPV. Annual Review of Public Health, 17, 69–84.
https://www.annualreviews.org/content/journals/10.1146/annurev.pu.17.050196.000441
7. Benard, V.B., Castle, P.E., Jenison, S.A., Hunt, W.C. (2017). Population-based incidence rates of cervical intraepithelial neoplasia in the HPV vaccine era. JAMA Oncology.
https://jamanetwork.com/journals/jamaoncology/article-abstract/2554749
8. Insinga, R.P., Perez, G., Wheeler, C.M. et al. (2011). Incident cervical HPV infections and progression to CIN. Cancer Epidemiology, Biomarkers & Prevention, 20(2), 287–296.
https://aacrjournals.org/cebp/article-abstract/20/2/287/68605
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