CHRONIC GENERALIZED PERIODONTITIS AND ITS SYSTEMIC COMPLICATIONS
Keywords:
chronic generalized periodontitis, systemic complications, alveolar bone loss, inflammatory disease, oral-systemic connection.Abstract
Chronic generalized periodontitis is a prevalent inflammatory disease
affecting the supporting structures of the teeth, leading to progressive alveolar bone
loss and eventual tooth loss. Beyond local oral manifestations, increasing evidence
indicates a strong association between periodontitis and systemic health conditions,
including cardiovascular diseases, diabetes mellitus, respiratory disorders, and adverse
pregnancy outcomes. This article provides a comprehensive review of the
pathophysiological mechanisms linking chronic generalized periodontitis with
systemic complications, highlighting the importance of early diagnosis, preventive
strategies, and interdisciplinary management to improve both oral and overall health
outcomes.
References
1. Preshaw P.M., Alba A.L., Herrera D., Jepsen S., Konstantinidis A., Makrilakis
K., Taylor R. Periodontitis and systemic health: current status. Journal of Clinical
Periodontology.
2. Lalla E., Papapanou P.N. Periodontal-systemic interactions: diabetes and
beyond. Journal of Dental Research.
3. Tonetti M.S., Van Dyke T.E. Periodontitis and systemic inflammation.
Periodontology 2000.
4. Offenbacher S. Periodontal disease and pregnancy outcomes. Annals of
Periodontology.
5. Kinane D.F., Stathopoulou P.G., Papapanou P.N. Periodontal diseases. Nature
Reviews Disease Primers.
6. Hajishengallis G., Chavakis T. Local and systemic mechanisms linking
periodontal disease and cardiovascular disease. Trends in Endocrinology &
Metabolism.
7. Bartold P.M., Van Dyke T.E. An appraisal of the role of specific bacteria in the
initial pathogenesis of periodontitis. Journal of Clinical Periodontology.
8. Tonetti M.S., Jepsen S., Jin L., Otomo-Corgel J. Impact of the global burden of
periodontal diseases on health, nutrition, and well
