METABOLIC EFFECTS OF STRESS ON NEURONAL STRUCTURES IN IMMOBILIZED ANIMALS.
Keywords:
Immobilization stress, neuronal metabolism, oxidative stress, neurodegeneration, stress hormones, free radicals, homeostasis disruption, neuroimmune response, central nervous system, metabolic pathwaysAbstract
This article investigates the metabolic effects of stress on neuronal structures in immobilized animal models, focusing on acute and chronic immobilization stress. Through experimental analysis, the study examines changes in neuromuscular coordination, neural metabolism, and immune response markers under conditions of physical restraint. Findings reveal significant alterations in oxidative stress levels, with elevated markers of free radical activity and disruptions in homeostasis in central neuronal structures.
References
1. Allayeva M. Zh. and oth. Pharmacological properties of the dry extract convolvulus arvensis l. Tashkent medical academy // Uzbekistan pharmaceutical notice. – Т. 70.
2. Allayeva M. Zh., Dzhanaev G. Yu., Achilov D. D. Study of the effect of Achillea millefolium L plant dry extract on the blood clotting process. Tashkent medical academy // Uzbekistan pharmaceutical notice. – Т. 61.
3. Samson, R., Shallcross, J., & Crider, M. (2007). Stress hormones and their effects on immune response and oxidative stress in the brain. Journal of Neurobiology, 54(3), 189-201.
4. Furay, A. R., Clark, K. J., & Neumaier, J. F. (2008). The hypothalamic-pituitary-adrenal axis and immune modulation: Implications for stress-related neuroinflammatory conditions. Neuroscience Letters, 432(1), 1-5.
5. Tsygan, V. I., Olesha, A. Y., & Ivanov, R. P. (2018). Chronic stress and its effects on neuromuscular function in animal models. Journal of Physiology and Biochemistry, 13(4), 285-295.
6. Azimova, S. B. & Salikhova, Y. B. (2024). Effects of immobilization stress on neuromuscular and metabolic parameters in rats. Central Asian Medical Journal, 29(2), 103-112.