ATHEROSCLEROSIS OF BLOOD VESSELS IS A MANIFESTATION OF COMPLICATIONS OF METABOLIC SYNDROME
Keywords:
morphology, elastic vessels, metabolic syndromeAbstract
Studying the nature and initial changes of the morphological changes observed as a result of hypokinesia and the consequences of the metabolic syndrome is an urgent medical problem. A high-calorie diet throughout life is considered one of the main causes of metabolic syndrome. In understanding the pathogenesis of metabolic syndrome and hypodynamia, it is important to know the morphological changes observed in these pathologies. As an object of research, we studied the morphological changes in arteries of elastic type. The obtained results revealed destructive and defragmentation changes in fibrous structures in the walls of elastic type arteries.
References
Andreeva S. A. Age-related transformation of the arterial part of the pulmonary circulation //FORCIPE. – 2022. – T. 5. – No. 1. – pp. 20-26.
Andreeva S. A., Dolgikh V. T. Structural and functional changes in the arteries of the pulmonary circulation in the long-term posthemorrhagic period // General resuscitation. – 2008. – T. 4. – No. 6. – pp. 27-33.
Andreevskaya M.V. et al. Assessment of the relationship between arterial stiffness parameters and metabolic syndrome criteria and various fat depots in patients with abdominal obesity // Systemic hypertension. – 2020. – T. 17. – No. 4. – pp. 53-60.
Hu S, Trieb M, Huang R, Tamalunas A, Keller P, Götz M, Waidelich R, Stief CG, Hennenberg M. Organ-specific off-target effects of Pim/ZIP kinase inhibitors suggest lack of contractile Pim kinase activity in prostate, bladder, and vascular smooth muscle. Naunyn Schmiedebergs Arch Pharmacol. 2024 Feb;397(2):1219-1231.
Jaminon A, Reesink K, Kroon A, Schurgers L. The Role of Vascular Smooth Muscle Cells in Arterial Remodeling: Focus on Calcification-Related Processes. // Int J Mol Sci. 2019 Nov 14;20(22):5694.
Jiménez-González S., Marín-Royo G., Jurado-López R., Bartolomé M.V., Romero-Miranda A., Luaces M. et al. The crosstalk between cardiac lipotoxicity and mitochondrial oxidative stress in the cardiac alterations in diet-induced obesity in rats. //Cells. 2020;9(2):451.
Kagota S, Maruyama-Fumoto K, Iwata S, Shimari M, Koyanagi S, Shiokawa Y, McGuire JJ, Shinozuka K. Perivascular Adipose Tissue-Enhanced Vasodilation in Metabolic Syndrome Rats by Apelin and N-Acetyl-Cysteine-Sensitive Factor(s). Int //J Mol Sci. 2018 Dec 28;20(1):106.
Kameshima S, Sakamoto Y, Okada M, Yamawaki H. Vaspin prevents elevation of blood pressure through inhibition of peripheral vascular remodeling in spontaneously hypertensive rats. //Acta Physiol (Oxf).2016 Jun;217(2):120-9.
Zelinskaya I, Kornushin O, Savochkina E, Dyachuk V, Vasyutina M, Galagudza M, Toropova Y. Vascular region-specific changes in arterial tone in rats with type 2 diabetes mellitus: Opposite responses of mesenteric and femoral arteries to acetylcholine and 5 -hydroxytryptamine.// Life Sci. 2021 Dec 1;286:120011.
Zhang Z, Li X, He J, Wang S, Wang J, Liu J, Wang Y. Molecular mechanisms of endothelial dysfunction in coronary microcirculation dysfunction. // J Thromb Thrombolysis. 2023 Oct;56(3):388-397.