EFFECTS OF FERULA TADSHIKORUM RESIN EXTRACT ON CELL VOLUME REGULATION IN RAT THYMOCYTES AND MEMBRANE INTEGRITY OF HUMAN ERYTHROCYTES

Authors

  • Fayziev Diyor Institute of Biophysics and biochemistry at the National university of Uzbekistan
  • Kurbannazarova Ranokhon Institute of Biophysics and biochemistry at the National university of Uzbekistan
  • Sabirov Ravshan Institute of Biophysics and biochemistry at the National university of Uzbekistan

Keywords:

Ferula tadshikorum, RVD, erythrocyte, thymocyte

Abstract

The study presents data on the ethanol extract of Ferula tadshikorum resin. It was found that the extract inhibits the cell volume regulation system in thymocyte cells and induces the formation of pores with a radius of ~3.3 nm in the erythrocyte membrane. The extract decreases the resistance of cells to osmotic and colloid-osmotic stress, with lytic effects occurring at concentrations <10 μg/mL, while sublytic effects are observed even at 1 μg/mL.

References

1. Iranshahi M., Rezaee R., Najaf Najafi M., Haghbin A., Kasaian J. (2018) Cytotoxic activity of the genus Ferula (Apiaceae) and its bioactive constituents. Avicenna J Phytomed 8(4): 296-312.

2. Khamraeva D.T., Khojimatov O.K., Uralov A.I. (2019) Growth and development of Ferula tadshikorum Pimenov in culture. Acta Biologica Sibirica 5(3): 172–177. DOI: 10.14258/abs.v5.i3.6588

3. Zhou Y., Xin F., Zhang G., Qu H., Yang D., Han X. (2017) Recent Advances on Bioactive Constituents in Ferula. Drug Dev Res 78(7): 321-331. DOI: 10.1002/ddr.21402

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Published

2025-12-03

Issue

Vol. 2 No. 10 (2025): CONFERENCE ON THE ROLE AND IMPORTANCE OF SCIENCE IN THE MODERN WORLD

Section

Articles

How to Cite

EFFECTS OF FERULA TADSHIKORUM RESIN EXTRACT ON CELL VOLUME REGULATION IN RAT THYMOCYTES AND MEMBRANE INTEGRITY OF HUMAN ERYTHROCYTES. (2025). CONFERENCE ON THE ROLE AND IMPORTANCE OF SCIENCE IN THE MODERN WORLD, 2(10), 250-251. https://universalconference.us/universalconference/index.php/crismw/article/view/6014