MIKROORGANIZMLARDAN YANGI DORI VOSITALARI ISHLAB CHIQISH
Keywords:
mikroorganizmlar; tabiiy mahsulotlar; genom-maynig; metagenomika; iChip; yangi antibiotiklar; sintetik biologiya; yuqori o‘lchovli skrining; dori kashfiyoti; rezistentlikAbstract
Ushbu maqola mikroorganizmlardan yangi dori vositalarini ishlab chiqishning nazariy va amaliy jihatlarini — tarixiy ildizlardan tortib zamonaviy genomining, metagenomik, kontsultivatsion texnologiya va sun’iy intellekt yordamida amalga oshirilayotgan dori-kashfiyot strategiyalarigacha — birlashtirib tahlil qiladi. Maqolada mikroorganizmlarning tabiiy mahsulotlari (secondary metabolites) biologik faollik va farmatsevtik potentsial nuqtai nazardan baholanadi, ixtirochi va sanoat laboratoriyalarida foydalanilayotgan genom-maynig va metabolomika yondashuvlari muhokama qilinadi, shuningdek, kritik muammolar — qiyin yetishtiriladigan bakteriyalar, rezistentlik, toksiklik va kimyoviy optimizatsiya — hamda ularni yengish strategiyalari yoritiladi. Amaliy misollar va so‘nggi tadqiqotlardan olingan natijalar, jumladan iChip metodi orqali teixobactin kashfiyoti, genom-maynig orqali yashirin biosintetik gen klasterlarini aniqlash hamda metagenomika va AI yordamida yangi bioaktiv molekulalarni aniqlash imkoniyatlari muhokama qilinadi.
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