CHRONIC ENDOMETRITIS IN WOMEN WITH PELVIC PAIN: DECODING PATHOGENESIS, ENHANCING DIAGNOSTICS, AND OPTIMIZING MULTIMODAL THERAPY
Keywords:
chronic endometritis, pelvic pain, reproductive health, microbial pathogenesis, molecular diagnostics, multimodal therapy, women’s health, fertility.Abstract
Chronic endometritis silently fuels pelvic pain in women, undermining reproductive health, yet its pathogenesis and optimal management remain enigmatic. This study explores the microbial and immune underpinnings of chronic endometritis in reproductive-age women in Uzbekistan, leveraging advanced diagnostics and multimodal therapies. A cohort of 120 women with pelvic pain was assessed via clinical exams, molecular assays, ultrasound, and hysteroscopy, identifying pathogens and immune markers. Treatments combined antibiotics, probiotics, and hormonal agents, evaluated over 6 months. Results revealed 52% endometritis prevalence, driven by Chlamydia and Ureaplasma, with elevated IL-6 signaling inflammation. Multimodal therapy reduced pain by 70% and restored endometrial health in 75% of cases. In Uzbekistan’s youthful population, these findings spotlight endometritis as a treatable pain driver, offering global insights into fertility preservation through integrated care.
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