EFFECT OF DCPIB ON THE CONTRACTILE ACTIVITY OF THE ISOLATED PERFUSED HEART

Authors

  • Oljaev Navruz Dilmurod ogli Institute of Biophysics and Biochemistry
  • Merzlyak Petr Institute of Biophysics and Biochemistry
  • Sabirov Ravshan Institute of Biophysics and Biochemistry

Keywords:

DCPIB; VSOR; HR; LVSP; LVEDP; LVDP

Abstract

The concentration-dependent effects of DCPIB were assessed in Langendorff-perfused hearts. Increasing doses of DCPIB caused a progressive decline in HR and ±dP/dt, while significantly elevating LVEDP. LVSP showed a slight, non-significant increase, and LVDP remained unchanged.

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References

1. Okada, Y., Sato-Numata, K., Sabirov, R. Z., & Numata, T. (2021). Cell death induction and protection by activation of ubiquitously expressed anion/cation channels. Part 2: Functional and molecular properties of ASOR/PAC channels and their roles in cell volume dysregulation and acidotoxic cell death. Frontiers in Cell and Developmental Biology, 9, 702317. doi.org/10.3389/fcell.2021.702317

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Published

2025-10-29

Issue

Vol. 2 No. 9 (2025): PROBLEMS AND SOLUTIONS OF SCIENTIFIC AND INNOVATIVE RESEARCH

Section

Articles

How to Cite

EFFECT OF DCPIB ON THE CONTRACTILE ACTIVITY OF THE ISOLATED PERFUSED HEART. (2025). PROBLEMS AND SOLUTIONS OF SCIENTIFIC AND INNOVATIVE RESEARCH, 2(9), 245-246. https://universalconference.us/index.php/pssir/article/view/5606