EFFECTS OF BROMSULFTHALEIN ON THE OSMOTIC RESISTANCE OF HUMAN RED BLOOD CELLS
Keywords:
Bromsulfthalein, human red blood cells, osmotic resistance, hemolysisAbstract
Bromsulfthalein (BSP) is a diagnostic agent used to assess liver function, and its concentration in bile may vary under certain pathological conditions. Studies have shown that BSP inhibits the volume-sensitive outwardly rectifying (VSOR) chloride channel in HeLa cells and the Maxi-Cl channel in C127 cells, thereby affecting the regulation of cell volume. Considering these properties, our experiments focused on evaluating the potential effects of bromsulfthalein on the stability of human red blood cells exposed to different osmotic stress conditions.
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References
1. Meri V Seeman. (2021) World History of the dopamine hypothesis of antipsychotic action. J Psychiatry. 19;11(7): 355-364. DOI:10.5498/wjp.v11.i7.355
2. M.W. Harrold, Y.A. Chang, R.A. Wallace, T. Farooqui, L.J. Wallace, N. Uretsky, D.D. Miller. (1987) Charged analogues of chlorpromazine as dopamine antagonists. J Med Chem. 1987 Sep;30(9):1631-5. DOI:10.1021/jm00392a019
3. Eslami Shahrbabaki M., Dehnavieh R., Vali L., Sharafkhani R. (2018) Chlorpromazine versus piperacetazine for schizophrenia. Cochrane Database Syst Rev. 31;10(10):CD011709. doi: 10.1002/14651858
4. Murawiec S. (2003) Subjective aspects of pharmacotherapy in schizophrenia during implementation of chlorpromazine in Poland-a review. Psychiatr Pol. 37(4):657-67. PMID: 14560494
