MORPHOLOGICAL CHANGES IN THE HIPPOCAMPUS RESULTING FROM STRESS

Bobir Xoshimov; Baxtiyor Kuylanov

Authors

Xoshimov Bobir Department of Clinical Sciences Alfraganus University, Tashkent, Uzbekistan
Kuylanov Baxtiyor Department of Clinical Sciences Alfraganus University, Tashkent, Uzbekistan

Keywords:

stress, hippocampus, neurocytes, morphology, neurogenesis, pathological changes, laboratory rats.

Abstract

This article examines the impact of chronic stress on the morphology of the hippocampus. The study compares the hippocampal structure and developmental dynamics of laboratory rat offspring born to stressed mothers with those in a control group. The results indicate that offspring exposed to stress exhibit a reduction in hippocampal neurocytes, vacuolization of the cytoplasm, changes in nuclear and cytoplasmic size, as well as neurocyte lysis. Additionally, the body weight of stressed rat offspring was found to be lower than that of the control group. The obtained data suggest that stress may have a negative impact on hippocampal structure.

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References

1. Behavioral deficits induced by third-trimester equivalent alcohol exposure in male C57BL/6J mice are not associated with reduced adult hippocampal neurogenesis but are still rescued with voluntary exercise / G. F. Hamilton [et al.] // Behavioural Brain Research. – 2016. – Vol. 314. – P. 96-105. – doi: 10.1016/j.bbr.2016.07.052.

2. Hippocampal abnormalities in youth with alcoholrelated neurodevelopmental disorder [Electronic resource] / J. Dubek [et al.] // Journal of the International Neuropsychological Society. – 2014. – Vol. 20, iss.– P. 181-191.

3. Alizadeh AA, Eisen MB, Davis RE, et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature. 2000;403(6769):503–511. doi: 10.1038/35000501

4. Perou CM, Sorlie T, Eisen MB, et al. Molecular portraits of human breast tumours. Nature. 2000;406(6797):747–752. doi: 10.1038/35021093.

5. Haibe-Kains B, Culhane A, Desmedt C, Bontempi G, Quackenbush J, Sotiriou C. Robustness of breast cancer molecular subtypes identification. Ann Oncol. 2010;21(suppl 4):iv49–iv59.

6. Liedtke C, Hatzis C, Symmans WF, et al. Genomic grade index is associated with response to chemotherapy in patients with breast cancer. J Clin Oncol. 2009;27(19):3185–3191. doi: 10.1200/JCO.2008.18.5934.

7. Teschendorff AE, Caldas C. The breast cancer somatic ʻmuta-omeʻ: tackling the complexity. Breast Cancer Res. 2009;11(2):301. doi: 10.1186/bcr2236.