HISTOMORPHOLOGICAL CHANGES IN INTERVERTEBRAL DISCS OF  OFFSPRING EXPOSED TO EXPERIMENTAL HYPOTHYROIDISM: THE  IMPACT OF HYPODYNAMIA

Boltayev Eshmamat

Authors

Boltayev Eshmamat

Keywords:

experimental hypothyroidism, hypodynamia, intervertebral disc, offspring, histomorphological changes, nucleus pulposus, annulus fibrosus, extracellular matrix, cartilage tissue, disc degeneration.

Abstract

This article examines the impact of hypodynamia on the histomorphological characteristics of intervertebral discs in offspring developed under conditions of experimental hypothyroidism. Particular attention is given to the potential structural alterations in the nucleus pulposus, annulus fibrosus, and cartilaginous endplates associated with thyroid hormone deficiency and reduced physical activity. The study focuses on changes in cellular organization, extracellular matrix composition, and
tissue architecture, emphasizing the possible combined effects of endocrine dysfunction and mechanical unloading.

Downloads

Download data is not yet available.

References

1. Bassett, J. H. D., & Williams, G. R. (2016). Role of thyroid hormones in skeletal development and bone maintenance. Endocrine Reviews, 37(2), 135–187. [https://doi.org/10.1210/er.2015-1106](https://doi.org/10.1210/er.2015-1106?utm_source=chatgpt.com)

2. Neidlinger-Wilke, C., Galbusera, F., Pratsinis, H., et al. (2014). Mechanical loading of the intervertebral disc: From the macroscopic to the cellular level. European Spine Journal, 23(Suppl. 3), S333–S343. [https://doi.org/10.1007/s00586-013-2855-9](https://doi.org/10.1007/s00586 013-2855-9?utm_source=chatgpt.com)

3. Stokes, I. A. F., & Iatridis, J. C. (2004). Mechanical conditions that accelerate intervertebral disc degeneration: Overload versus immobilization. Spine, 29(23), 2724–2732. [https://doi.org/10.1097/01.brs.0000146049.52152.da](https://doi.org/10.1097/01.brs. 0000146049.52152.da?utm_source=chatgpt.com)

4. Urban, J. P. G., & Roberts, S. (2003). Degeneration of the intervertebral disc. Arthritis Research & Therapy, 5(3), 120–130. [https://doi.org/10.1186/ar629](https://doi.org/10.1186/ar629?utm_source=chatgpt.co m)

5. Williams, G. R. (2013). Thyroid hormone actions in cartilage and bone. European Thyroid Journal, 2(1), 3–13. [https://doi.org/10.1159/000345548](https://doi.org/10.1159/000345548?utm_source =chatgpt.com)