Reproductive, Metabolic, and Cardiovascular Consequences of Premature Ovarian Insufficiency: A Critical Integrative Review of Clinical Evidence, RealWorld Data, and Precision Care
Keywords:
premature ovarian insufficiency; ovarian failure; hypoestrogenism; infertility; reproductive aging; cardiometabolic risk; cardiovascular disease; boneAbstract
Premature ovarian insufficiency (POI), defined by impaired ovarian activity before 40 years of age, represents a multisystem diagnosis rather than an isolated fertility disorder. Its consequences involve hypoestrogenism, intermittent ovarian function, impaired reproductive autonomy, skeletal vulnerability, cardiometabolic risk, and substantial psychosocial burden. Objective: To critically integrate contemporary evidence regarding reproductive, metabolic, and cardiovascular sequelae of POI, and to assess how real-world evidence and computational tools may improve longitudinal care. Methods:
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References
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