PREDICTIVE VALUE OF CLINICAL AND NEUROPSYCHOLOGICAL INDICATORS FOR THE EFFECTIVENESS OF PREVENTIVE THERAPY IN MIGRAINE
Keywords:
migraine, preventive therapy, predictors, CGRP, neuropsychology, depression, anxiety, MIDAS, HIT-6.Abstract
Response to preventive migraine therapy varies considerably among patients. This thesis summarizes the predictive significance of clinical phenotype, disease burden, psychoemotional status, and cognitive-executive functioning for treatment outcomes. Current evidence suggests that unilateral pain, cranial autonomic symptoms, good response to triptans, and a relatively lower baseline disease burden may be associated with a favorable response to selected CGRP-targeted therapies. In contrast, chronic migraine, high MIDAS/HIT-6 scores, obesity, depressive and anxiety symptoms, and multiple previous preventive treatment failures are associated with less favorable outcomes. A multidimensional assessment may therefore improve individualized preventive treatment planning.
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References
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