THE SUCCESSION OF INTESTINAL MICROBIOTA IN CONDITIONS OF EXPERIMENTAL POST-CHOLECYSTECTOMY SYNDROME

Nurullayeva Sh.M; Tastanova G.Y; A.M. Xaydarov

Authors

Nurullayeva Sh.M Samarkand State Medical University, Tashkent City Emergency Medical Care Clinical Hospital, Tashkent, Uzbekistan
Tastanova G.Y Samarkand State Medical University, Tashkent City Emergency Medical Care Clinical Hospital, Tashkent, Uzbekistan
A.M. Xaydarov

Keywords:

Cholecystectomy; gut microbiota; dysbiosis; bile acids.

Abstract

Cholecystectomy is a frequently conducted surgical intervention that modifies the storage and secretion of bile acids, resulting in a continuous flow of bile and a disruption of the enterohepatic circulation. These changes may lead to increased exposure of the colon to bile acids and an imbalance in gut microbiota, potentially triggering intestinal inflammation, metabolic irregularities, and various long-term complications. Nevertheless, the precise mechanisms and clinical ramifications of these alterations remain inadequately elucidated. This review seeks to consolidate existing evidence regarding the effects of cholecystectomy on the composition of gut microbiota and its possible links to metabolic changes and clinical outcomes.

This study emphasizes the importance of regular bacteriological examinations in patients with fever persisting beyond seven days, as well as the identification of pathogenic serovars, their virulence factors, and antibiotic susceptibility profiles.