CLINICAL AND LABORATORY FEATURES OF CHANGES IN THE COAGULATION SYSTEM IN PATIENTS WITH CHRONIC PANCREATITIS

Abstract

Chronic pancreatitis is a long-term inflammatory and degenerative disease of the pancreas accompanied by exocrine and endocrine insufficiency, systemic inflammation, metabolic disorders and microcirculatory disturbances. In prolonged and recurrent disease, toxic-metabolic factors such as alcohol consumption and smoking, as well as hepatobiliary comorbidity, may lead to multidirectional changes in the blood coagulation system. Hemostatic disorders in chronic pancreatitis may manifest either as hypercoagulation or hypocoagulation, increasing the risk of thrombotic and hemorrhagic complications.