ANTIBIOTIC SYNTHESIS FROM MICROORGANISMS

Chariyev Nuriddin; Keldiyarova Halena; Pardayev Og‘abek; Almardonova Gullola

Authors

Chariyev Nuriddin Assistant Professor, Department of Social and Humanitarian Sciences, Tashkent State Medical University
Keldiyarova Halena 1st year undergraduate students of TDTU Termez branch
Pardayev Og‘abek 1st year undergraduate students of TDTU Termez branch
Almardonova Gullola 1st year undergraduate students of TDTU Termez branch

Keywords:

Antibiotics, microorganisms, fermentation, Cephalosporin C, 7-ACA, Ceftriaxone sodium, Azobact, biotechnology.

Abstract

This article discusses the process of synthesizing antibiotics from microorganisms, their biological significance, and the possibilities of their industrial application. The study specifically analyzes bacteria belonging to the Acremonium chrysogenum, Streptomyces genera, and their role in the synthesis of beta-lactam antibiotics (Cephalosporin C, Ceftriaxone sodium, Azobact). The article consistently describes the fermentation process, the formation of 7-aminocephalosporanic acid (7-ACA) from Cephalosporin C, as well as the stages of the production of Ceftriaxone sodium through chemical modification. The results of the study show that the production of antibiotics based on microorganisms is not only an economically affordable, but also an environmentally safe and highly efficient biotechnological route. This approach can also serve as the main source for the creation of new types of antibiotics in the future.

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