POSTOPERATIVE COMPLICATIONS IN DISSEMINATED PERITONITIS AND FACTORS OF THEIR DEVELOPMENT
Keywords:
generalized peritonitis, postoperative complications, laparotomy, staged sanitation of the abdominal cavity.Abstract
A retrospective analysis of the complication structure in 175 patients with peritonitis was performed depending on the method of surgical treatment. It was found that true laparostomy is accompanied by the maximum risk of wound edge retraction (71.4%), nosocomial infection (76.2%), and general complications. "Semi-open" staged sanitation of the abdominal cavity reduces the risk of purulent wound complications by 2.5–2.9 times (F = 0.025), acute respiratory failure — by 1.8 times (F = 0.277), moderately increasing the risk of nosocomial infection. "Semi-closed" treatment method is associated with a high risk of wound suppuration and respiratory failure.
Downloads
References
1. Analysis of the clinical picture in patients of the control group with RP showed a high frequency of postoperative complications (65.5%), one or more peritoneal and/or systemic complications were recorded. The most frequent peritoneal complications were intra-abdominal abscesses, recurrent RP, anastomotic failure and early adhesive intestinal obstruction.
2. Dynamic observation showed that systemic complications developed mainly in the first 1-4 days of POP and were associated with early TS, SS, homeostasis disorder, while peritoneal complications formed within 5-10 days of POP, which corresponds to the phase of local inflammation and secondary infection
LITERATURE:
1. Akperov I.A., Butenko Yu.A., Gutsulyak A.I. Multi-stage operations in the treatment of diffuse purulent peritonitis // Fundamental and applied research in the modern world. - 2019. - No. 25. - P. 28-31. - EDN YYHMIP.
2. Bashir M., Davlitsarov M.A., Tsybin A.A., et al. Clinical manifestation of diffuse appendicular peritonitis in a 3-year-old child // Pediatric surgery. - 2021. - Vol. 25, No. S1. - P. 22. - EDN FEQMJJ.
3. Bityukov S.L., Demidenko V.V. Efficiency of using the Mannheim Peritonitis Index in predicting complications and mortality in diffuse peritonitis // Morphological Almanac named after V.G. Koveshnikov. - 2019. - Vol. 17, No. 3. - P. 14-18. - EDN KLNKHX.
4. Orozoev U.D., Kadyrkulov A.Zh. Scale for diagnosing acute appendicitis to prevent diffuse peritonitis in children // Bulletin of Science and Practice. - 2024. - Vol. 10, No. 7. - P. 305-308. DOI: 10.33619/2414-2948/104/32. - EDN WNDUPF.
5. Meng R., Guan X., Sun L., et al. The efficacy and safety of eravacycline compared with current clinically common antibiotics in the treatment of adults with complicated intra-abdominal infections: a Bayesian network meta-analysis // Frontiers in Medicine (Lausanne). — 2022. — Vol. 9. - Article 935343. DOI: 10.3389/fmed.2022.935343.
6. Monti G., Bradic N., Marzaroli M., et al. Continuous vs intermittent meropenem administration in critically ill patients with sepsis: the MERCY randomized clinical trial // JAMA. — 2023. — Vol. 330, No. 2. - P. 141–151. DOI: 10.1001/jama.2023.12909
7.Khamdamova M.T., Akramova D. E. Genetic aspects of genital prolapse in women of reproductive age // New day in medicine. Bukhara, 2023. - No. 5 (55). - Р. 638-643.
8. Khamdamova M.T., Teshaev Sh.Zh., Hikmatova M.F. Morphological changes of the thymus and spleen in renal failure in rats and correction with pomegranate seed oil // New day in medicine. Bukhara, 2024. - N. 3(65). - Р. 167-187.
9. Khamdamova M.T., Khasanova M.T. Various mechanisms of pathogenesis of endometrial hyperplasia in postmenopausal women (literature review) // New day in medicine. Bukhara. 2023. - No. 8 (58). - Р. 103-107.
10. Khamdamova M.T., Zhaloldinova M.M., Khamdamov I.B. The state of nitric oxide in blood serum in patients with cutaneous leishmaniasis // New day in medicine. Bukhara, 2023. - No. 5 (55). - Р. 638-643.
11. Khamdamova M.T., Zhaloldinova M.M., Khamdamov I.B. The value of ceruloplasmin and copper in blood serum in women wearing copper-containing intrauterine device // New day in medicine. Bukhara, 2023. - No. 6 (56). - Р. 2-7.
12. Khamdamova M.T., Akramova D. E. Immediate and long-term results of surgical treatment of genital prolapse in elderly women // New day in medicine. Bukhara, 2025. - N3 (77). - Р. 201-206.
13. Khamdamova M. T., Khasanova M.T. Genetic mechanisms of development of endometrial hyperplastic processes in women in menopacteric age // New day in medicine. Bukhara, 2025. - N3 (77). - Р. 207-211.
14. Khamdamova M. T., Umidova N. N. Genetic factors of genital endometriosis // New day in medicine. Bukhara, 2025. – N4 (78). - Р. 82-87.
15. Efgan, M. G.; Akar, H.; Kanter, E.; Kirik, S.; Duman Shahan, T. Role of systemic immune inflammation index, systemic immune response index, neutrophil lymphocyte ratio, and platelet ratio in predicting peritoneal culture positivity and prognosis in patients with spontaneous bacterial peritonitis admitted to the emergency department. Medicina 2024 , 60 , 1335.
16. Sartelli M., Coccolini F., Kluger Y., et al. WSES guidelines for management of intra-abdominal infections // World Journal of Emergency Surgery. — 2021. — Vol. 16. - Article No. 49. DOI: 10.1186/s13017-021-00381-6



















