THE INFLUENCE OF INTESTINAL MICROBIOTA ON GLUCOSE METABOLISM

Akhmadova Durdona Kamol Kizi

Authors

Akhmadova Durdona Kamol Kizi student of the TMA Termez branch, 4-course, Faculty of General Medicine.

Keywords:

gut microbiota, glucose metabolism, insulin resistance, probiotics, prebiotics , type 2 diabetes, SCFA, dysbiosis , inflammation, gut barrier, glucose, lipopolysaccharides , microbiome , metformin , metabolic syndrome

Abstract

The article examines the relationship between the state of the intestinal microbiota and the regulation of glucose metabolism. It highlights the mechanisms by which intestinal microbes affect insulin sensitivity, inflammation, and energy homeostasis. It describes the factors that change the composition of the microbiota and their consequences for the risk of developing type 2 diabetes. It presents modern methods for correcting the intestinal microflora and the possibilities of using probiotics and prebiotics in the prevention of carbohydrate metabolism disorders. It emphasizes the potential of the microbiota as a therapeutic target in the future.

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References

1. Ardatskaya M.D., Kasyanova I.N. The role of intestinal microbiota in the pathogenesis of type 2 diabetes mellitus // Russian Journal of Gastroenterology, Hepatology, Proctology. - 2023. - No. 4. - P. 12-18.

2. American Diabetes Association. Gut Microbiome and Diabetes: Scientific Review. Diabetes Care . 2024;47(1):15–25.

3. Le Chatelier E. et al. Richness of human gut microbiome correlates with metabolic markers. Nature . 2022;500(7464):541–546.

4. Falony G. et al. Population-level analysis of gut microbiome variation. Science . 2022;352(6285):560–564.

5. Cani PD et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes . 2023;72(4):1126–1134.

6. Wu GD et al. Linking long-term dietary patterns with gut microbial enterotypes. Science . 2021;334(6052):105–108.