CHRONIC INFLAMMATION AND OXIDATIVE STRESS IN ENDOMETRIOSIS-ASSOCIATED INFERTILITY
Keywords:
endometriosis; infertility; oxidative stress; reactive oxygen species; iron overload; macrophages; cytokines; implantation; follicular microenvironment; realworld evidence; target trial emulation; artificial intelligence; reproductive outcomesAbstract
Endometriosis-associated infertility is a heterogeneous syndrome in which distorted pelvic anatomy interacts with immune dysregulation, iron-dependent oxidative injury, altered follicular and peritoneal environments, and endometrial receptivity. Objective: To critically integrate mechanistic and clinical evidence and examine whether real-world analytics can improve decisions without overstating the validity of candidate biomarkers. Methods: This integrative narrative review prioritizes 2022 ESHRE endometriosis guideline, recent systematic reviews, randomized trials, and regulatory guidance on real -world evidence and responsible artificial intelligence.
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References
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