PATHOGENIC AND IMMUNOMODULATING PROPERTIES OF TITANIUM DIOXIDE
Keywords:
titanium dioxide nanoparticles; rats; stomach; pro- and antioxidant activity; biochemical blood parameters.Abstract
In chronic experiments on rats, a study was carried out of the biological effect of nano- or microparticles of titanium dioxide (TiO2) upon physiological intake through the gastrointestinal tract. It has been established that after the physiological intake of TiO2 nanoparticles (δ50 12 nm, Ssp 95 m2/g) at a dose of 250 mg/kg body weight through the gastrointestinal tract, disturbances in the processes of formation and degradation of the parietal mucous layer of the stomach and increased erosive damage to the gastric mucosa are observed. , increased pro- and antioxidant activity parietal mucus. This may be a manifestation of the body’s compensatory reaction to the intake of TiO2 nanoparticles. Biochemical parameters in the blood of rats treated with nano- or microparticles of TiO2 demonstrate the absence of significant disturbances in the studied body systems under the conditions of our experiment.
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Алимбетова Г.З., Гайнуллина М.К. Профессиональный риск нарушения
репродуктивного здоровья женщин-работниц производства искусственных
кож // Успехи современного естествознания. 2014. № 12. С. 31–32.
Артамонова В.Г., Мухин Н.А.Профессиональные болезни. – М.: Медицина,
480 с.
INTERNATIONAL CONFERENCE ON
ADVANCE SCIENCE AND TECHNOLOGY
Volume 01, Issue 03, 2024
INTERNATIONAL CONFERENCE ON ADVANCE SCIENCE AND TECHNOLOGY universalconference.us
Байдюк О.Н. Гигиена и физиология труда женщин, занятых в современном
производстве суперфосфатов: автореф. дисс…. канд. мед. наук. – Омск, 2015.
с.
Данилин В.А. Особенности влияния на организм комплекса токсических
веществ производства СКИ-3 в малых концентрациях (клиникоэкспериментальное исследование): автореф. дисс.... докт. мед. наук. –
Горький, 2021. 36 с.
Khamdamov I.B. Clinical evaluation of the effectiveness of the traditional
approach to the treatment of hernias of the anterior abdominal wall in women of
fertile age // Doctor's Bulletin. –Samarkand 2022. No. 2.2 (104).-P.65-70.
Khamdamov I.B., Mirkhodzhaev I.A. Khakimov M.Sh. Khamdamov B.Z.
Evolution of the use of polymer implants for hernioplasty // Tibbiyotda Yangi kun.
– Tashkent; 2021,- No. 2 (34) P.-107-111.
Khamdamov I.B., Khamdamov A.B. Differentiated approach to the choice of
hernioplasty method in women of fertile age (Clinical and experimental study) //
Tibbiyotda Yangi kun. – Bukhoro, 2021.-No. 6 (38/1).-P. 112-114.
Khakimov M.Sh., Urmanova N.M., Khudoiberdiev S.S., Khamdamov I.B.
Possibilities of allohernioplasty in women of fertile age // Nazariy va clinic tibbiyot
journals. Tashkent.-2022.-No.3.P.89-93.
Khamdamov I.B., Khamdamov A.B. Fertil yoshdagi ayollarda endovideo surgeon
hernioplasty // Tibbiyotda yangi kun. Bukhoro, 2021.-№6 (38/1) -S. 25-27.
Khamdamov I.B. Experimental determination of the extensibility of the anterior
abdominal wall tissues at different times of pregnancy using various approaches to
hernioplasty // Academicia: An International Multidisciplinary Research Journal
Vol. 12, Issue 04, April 2022 SJIF 2022 = 8.252 R.193-201 (Scopus).
Khamdamov I.B. Improving tactical approaches in the treatment of hernias of
the anterior abdominal wall in women of fertile age // Tibbiyotda Yangi kun.
Bukhoro, 2022.-№10(48)- pp. 338-342.
Khamdamov I.B. Morphofunctional features of the abdominal press in women
of reproductive age // Tibbiyotda Yangi kun. Bukhoro, 2022.-№3(41)- pp. 223-227.
Khamdamova M.T. Ultrasound features of three-dimensional echography in
assessing the condition of the endometrium and uterine cavity in women of the first
period of middle age using intrauterine contraceptives // Biology va tibbyot
muammolari. - Samarkand, 2020. - No. 2 (118). - P.127-131.
Khamdamova M. T. Ultrasound аssessment оf changes in the endometrium of
the uterus in women of the first and second period of middle age when using
INTERNATIONAL CONFERENCE ON
ADVANCE SCIENCE AND TECHNOLOGY
Volume 01, Issue 03, 2024
INTERNATIONAL CONFERENCE ON ADVANCE SCIENCE AND TECHNOLOGY universalconference.us
intrauterine and oral contraceptives // Биомедицина ва амалиёт журнали. –
Ташкент, 2020. - №2. - 8 часть. - С.79-85.
Khamdamova M. T. Аnthropometric characteristics of the physical status of
women in the first and second period of middle age // A new day in medicine.
Tashkent, 2020. - № 1 (29). - C.98-100.
Khamdamova M.T. Age-related and individual variability of the shape and size
of the uterus according to morphological and ultrasound studies // News of
dermatovenereology and reproductive health. - Tashkent, 2020. - No. 1-2 (88-80). -
P.49-52.
Khamdamova M. T. Аnthropometric characteristics of the physical status of
women in the first and second period of middle age // Тиббиётда янги кун.
Ташкeнт, 2020. - № 1 (29). - C.98-100.
Khamdamova M.T. Age-related and individual variability of the shape and size
of the uterus according to morphological and ultrasound studies // News of
dermatovenereology and reproductive health. - Tashkent, 2020. - No. 1-2 (88-80). -
P.49-52.
Khamdamova M.T. Ultrasound features of three-dimensional echography in
assessing the condition of the endometrium and uterine cavity in women of the first
period of middle age using intrauterine contraceptives // Biology va tibbyot
muammolari. - Samarkand, 2020. - No. 2 (118). - P.127-131.20.Khamdamova M. T.
Ultrasound аssessment оf changes in the endometrium of the uterus in women of the
first and second period of middle age when using intrauterine and oral contraceptives
// Biomedicine va amaliyot journals. – Tashkent, 2020. - No. 2. - Part 8.- С.79-85.
Khamdamova M.T. Features of ultrasound parameters of the uterus in women of
the first and second period of middle age using injection contraceptives // Tibbiyotda
yangi kun. - Tashkent, 2020. - No. 2/1 (29/1). - pp.154-156.
Khamdamova M.T. Features of ultrasound images of the uterus and ovaries in
women of the second period of middle age using combined oral contraceptives //
Tibbiyotda yangi kun. - Tashkent, 2020. - No. 2 (30). - pp. 258-261.
Khamdamova M.T. Individual variability of the uterus and ovaries in women
who use and do not use various types of contraceptives // Tibbiyotda yangi kun. -
Tashkent, 2020. - No. 3 (31). - pp. 519-526.24.Khamdamova M. T. Еchographic
features variability in the size and shape of the uterus and ovaries in women of the
second period of adulthood using various contraceptives // Asian Journal of
Multidimensional Research - 2020. – N9 (5). - P.259-263.
INTERNATIONAL CONFERENCE ON
ADVANCE SCIENCE AND TECHNOLOGY
Volume 01, Issue 03, 2024
INTERNATIONAL CONFERENCE ON ADVANCE SCIENCE AND TECHNOLOGY universalconference.us
Khamdamova M. T. Somatometric characteristics of women of the first and
second period of adulthood using different contraceptives with different body types
// The american journal of medical sciences and pharmaceutical research - 2020. –
N8 (2). - P.69-76.
Хамдамова М.Т., Жалолдинова М.М.,Хамдамов И.Б. Состояние оксида
азота в сыворотке крови у больных кожным лейшманиозом // Тиббиётда янги
кун. - Бухоро, 2023. - № 5 (55). - C. 638-643.
Хамдамова М.Т., Жалолдинова М.М.,Хамдамов И.Б. Значение
церулоплазмина и меди в сыворотки крови у женщин носящих
медьсодержащих внутриматочной спирали // Тиббиётда янги кун. - Бухоро,
- № 6 (56). - C. 2-7.
Khamdamova M. T. Bleeding when wearing intrauterine contraceptives and
their relationship with the nitric oxide system // American journal of pediatric
medicine and health sciences Volume 01, Issue 07, 2023 ISSN (E): 2993-2149. Р.58-
Khamdamova M. T. The state of local immunity in background diseases of
the cervix // Eurasian journal of medical and natural sciences Innovative Academy
Research Support Center.Volume 3 Issue 1, January 2023 ISSN 2181-287X Р.171-
Хамдамова М.Т., Хасанова М.Т. Различные механизмы патогенез
гиперплазии эндометрия у женщин постменопаузального периода (обзор
литературы) // Тиббиётда янги кун. - Бухоро, 2023. - № 8 (58). - C. 103-107.
Khamdamova M. T., Khasanova Makhfuza Toyqulovna, Umidova Nigora
Nabievna The role of genetic determinants in the occurrence of hyperplastic
processes of the reproductive system of women’s menopausal age // Journal of
Advanced Zoology ISSN: 0253-7214 Volume 44 Issue Special Issue-2 Year 2023
Page 3724:3730
Измеров Н.Ф., Каспаров А.А. Медицина труда. Введение в специальность.
– М.: Медицина, 2012. 392 с.
Косарев В.В., Бабанов С.А. Профессиональные болезни. – М.: ГЭОТАРмедиа, 2017. 368 с.
