DEVELOPMENT OF THE RESPIRATORY SYSTEM IN ADOLESCENCE
Keywords:
adolescent respiratory system development, lung growth, bronchial tree maturation, chest wall expansion, sex differences, respiratory health, asthma, air pollutionAbstract
During adolescence (17–21 years), the respiratory system undergoes significant structural and functional changes to support increasing metabolic demands and ensure lifelong respiratory health. This review examines key aspects of respiratory system maturation, including alveolarization, lung volume growth, bronchial tree development, respiratory muscle strength, and improved chest wall compliance. Sex differences are highlighted: lung development in males continues significantly during puberty, while in females, it stabilizes earlier. The clinical significance of these changes, particularly in relation to diseases like asthma and environmental factors such as air pollution, is discussed. Understanding these processes enables healthcare professionals to better address adolescent respiratory issues and promote optimal lung health in adulthood [1-12].
Downloads
References
1. Di Cicco M, et al. Structural and functional development of airways in childhood: children are not small adults. Pediatr Pulmonol. 2021;56(1):240-51. doi:10.1002/ppul.25169.
2. Wang X, Dockery DW, Wypij D, Fay ME, Ferris BG. Pulmonary function between 6 and 18 years of age. Pediatr Pulmonol. 1993;15(2):75-88.
3. Sherrill DL, Camilli A, Lebowitz MD. On the temporal relationships between lung function and somatic growth. Am Rev Respir Dis. 1989;140(3):638-44.
4. Lebowitz MD, Sherrill DL. The assessment and interpretation of spirometry during the transition from childhood to adulthood. Pediatr Pulmonol. 1995;19(3):143-9.
5. Underwood LE, Van Wyk JJ. Normal and aberrant growth. In: Wilson JD, Foster DW, editors. Williams textbook of endocrinology. 8th ed. Philadelphia, PA: WB Saunders Company; 1992. p. 1079-138.
6. Shrader PC, Quanjer PH, Olievier IC. Respiratory muscle strength and ventilatory function in adolescents. Eur Respir J. 1984;65(6):368-75.
7. Dimeglio A, Canavese F. The growing spine: how spinal deformities influence normal spine and thoracic cage growth. Eur Spine J. 2012;21(1):64-70. doi:10.1007/s00586-011-1983-3.
8. Global Initiative for Asthma. Global strategy for asthma management and prevention. 2025
9. Lung Function Equations [Internet]. 2025 [cited 2025 May 15]. Available from: http://www.lungfunction.org/tools/90-equations-and-tools.
10. Pesce G, et al. Lung function changes from childhood to adolescence: a seven-year follow-up study. BMC Pulm Med. 2015;15:30. doi:10.1186/s12890-015-0023-5.
11. van der Walt M, et al. Developmental respiratory physiology. BJA Educ. 2022;22(5):185-91. doi:10.1016/j.bjae.2022.01.005.
12. Rosenthal M, et al. Lung and chest wall development in adolescence: relationship with pubertal status. Eur Respir J. 2002;20(5):1292-9. doi:10.1183/09031936.02.00000102.



















